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  Indian J Med Microbiol
 

Figure 5: Tangshen formula blocks activation of the transforming growth factor β1/Lnc RNA MEG3/Smad3 signaling pathway in diabetic rats. Tangshen formula treatment inhibits expression of the Lnc RNA MEG3 (a), immunohistochemistry of transforming growth factor β1 and p-Smad2/3(original magnification (×400), scale bars, 50 μm) (b), quantitative analysis of transforming growth factor β1, quantitative analysis of nucleated p-Smad2/3 in glomeruli, and tubulointerstitium (c), western blot of Smad3 and p-Smad3 (d), and semi-quantitative analysis of p-Smad3 (e). Data are expressed as means ± standard error for each group of 6 rats. #P < 0.05, ###P < 0.001, diabetic kidney disease group versus Sham group; *P < 0.05, ***P < 0.001, diabetic kidney disease + Tangshen formula group versus diabetic kidney disease group

Figure 5: Tangshen formula blocks activation of the transforming growth factor β1/Lnc RNA MEG3/Smad3 signaling pathway in diabetic rats. Tangshen formula treatment inhibits expression of the Lnc RNA MEG3 (a), immunohistochemistry of transforming growth factor β1 and p-Smad2/3(original magnification (×400), scale bars, 50 μm) (b), quantitative analysis of transforming growth factor β1, quantitative analysis of nucleated p-Smad2/3 in glomeruli, and tubulointerstitium (c), western blot of Smad3 and p-Smad3 (d), and semi-quantitative analysis of p-Smad3 (e). Data are expressed as means ± standard error for each group of 6 rats. <sup>#</sup><i>P</i> < 0.05, <sup>###</sup><i>P</i> < 0.001, diabetic kidney disease group versus Sham group; *<i>P</i> < 0.05, ***<i>P <</i> 0.001, diabetic kidney disease + Tangshen formula group versus diabetic kidney disease group