Integrative Medicine in Nephrology and Andrology

REVIEW ARTICLE
Year
: 2021  |  Volume : 8  |  Issue : 1  |  Page : 5-

New insights into the immunity and podocyte in glomerular health and disease: From pathogenesis to therapy in proteinuric kidney disease


Paulina X Medina Rangel, Anupama Priyadarshini, Xuefei Tian 
 Section of Nephrology, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA

Correspondence Address:
Dr. Xuefei Tian
300 Cedar St., TAC S370, New Haven, Connecticut 06519
USA

Evidence has been furnished that immune cells, and immune-podocytes interactions have increasingly become the focus of proteinuric kidney diseases, which affect millions of patients worldwide. Podocytes are highly specialized, terminally differentiated epithelial cells that wrap around the glomerulus to maintain the integrity of the glomerular filtration barrier. More recent studies demonstrate that podocytes express many elements of the innate and adaptive immune system including the complement components and receptors, through which podocytes can be involved in immune-mediated glomerular injuries and as a therapeutic target to alleviate the podocyte injury and progression to chronic kidney disease. The present review will shed light on recent findings, which have furthered our understanding of the immune mechanisms involved in podocyte injury, as well as the therapeutic implications in the treatment of immune-mediated glomerular injury.


How to cite this article:
Medina Rangel PX, Priyadarshini A, Tian X. New insights into the immunity and podocyte in glomerular health and disease: From pathogenesis to therapy in proteinuric kidney disease.Integr Med Nephrol Androl 2021;8:5-5


How to cite this URL:
Medina Rangel PX, Priyadarshini A, Tian X. New insights into the immunity and podocyte in glomerular health and disease: From pathogenesis to therapy in proteinuric kidney disease. Integr Med Nephrol Androl [serial online] 2021 [cited 2022 May 23 ];8:5-5
Available from: http://www.journal-imna.com/article.asp?issn=WKMP-0247;year=2021;volume=8;issue=1;spage=5;epage=5;aulast=Medina;type=0