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REVIEW ARTICLE
Year : 2022  |  Volume : 9  |  Issue : 1  |  Page : 5

Drug-induced acute kidney injury: Epidemiology, mechanisms, risk factors, and prevention via traditional chinese medicine


Department of Nephrology, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China

Correspondence Address:
Prof. Xuezhong Gong
Department of Nephrology, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, 274 Zhijiang Middle Road, Shanghai 200071
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2773-0387.345767

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Drug-induced nephrotoxicity is a common cause of acute kidney injury (AKI), and drug-induced AKI (DI-AKI) is becoming a serious public health concern. DI-AKI can be triggered by multiple drugs, alone or in combination. The incidence, pathological mechanisms, and risk factors of DI-AKI are largely unknown. Thus, there is a need for greater monitoring of DI-AKI to reduce the risks of serious complications and other hazards related to DI-AKI. This review summarizes the epidemiology of DI-AKI, along with its potential pathogenesis, associated drugs, independent risk factors, and possible early biomarkers. Additionally, because certain traditional Chinese medicine (TCM) prescriptions and their components have been reported to prevent and treat some types of DI-AKI (e.g., contrast-induced AKI), this review summarizes TCM methods for the prevention and treatment of DI-AKI.


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