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Clinical analysis of kidney injury in elderly patients with COVID-19
Yang Liu1, Chao- Chen Wang2, Qiang- Guo Ao1, Jie- Bin Hou1, Lei Wei3, Feng- Yu Qi4, Wei He2, Jia- Hui Zhao1, Qiang Ma1, Xiao- Hua Wang1, Qing- Li Cheng1, Guang Yang1
1 Department of Nephrology, National Clinical Research Centre for Geriatric Diseases, The Second Medical Center, Chinese PLA General Hospital, Beijing 100853, China
2 Department of Priority Medical, The Central Theater Command General Hospital of Chinese People's Liberation Army, Wuhan 430070, Hubei Province, China
3 Department of Health Medical, The Central Theater Command General Hospital of Chinese People's Liberation Army, Wuhan 430070, Hubei Province, China
4 Department of Orthopedics, The Central Theater Command General Hospital of Chinese People's Liberation Army, Wuhan 430070, Hubei Province, China
Correspondence Address:
Prof. Qing- Li Cheng
Department of Nephrology, National Clinical Research Centre for Geriatric Diseases, The Second Medical Center, Chinese PLA General Hospital, Beijing 100853
China
 Source of Support: None, Conflict of Interest: None
DOI: 10.4103/imna.imna_13_21
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Objective: The aim of the study was to analyze the clinical features of elderly patients with coronavirus disease 2019 (COVID-19) and to explore the relationship between COVID-19 patients and kidney injury. Methods: A total of 188 elderly patients with confirmed COVID-19 enrolled in this study were hospitalized for at least 1 week in the Central Theater Command General Hospital of Chinese People's Liberation Army from January 3, 2020 to March 14, 2020. The recorded information included clinical data and results of kidney-related laboratory tests. Retrospective analysis was performed. Results: The median age of the patients was 69 years (interquartile range 65–78, range: 60–97 years); 31.4% were 60–74 years old, and 68.6% were over 75 years old. A total of 12.8% and 18.6% of the patients were in critical and severe stages of COVID-19, respectively. The proportions of patients using mechanical ventilators and deaths were 9.5% and 8.5%, respectively. A total of 26.1% and 8.5% of the patients showed mild elevation of blood urea nitrogen (BUN) and serum creatinine (SCr) levels at admission. A total of 18.6% and 5.9% of the patients had elevated BUN and SCr 1 week after admission, respectively. A total of 3.1% of the patients were diagnosed with acute kidney injury, and 75% of those patients had chronic kidney disease before admission. Compared with the patients aged 60–74 years, those over 75 years exhibited significantly increased proportions of elevated BUN levels, critical illness, use of mechanical ventilated, and death. Multivariate logistic regression analysis revealed that an elevated BUN level at admission and 1 week after admission were independent risk factors for death in the elderly patients with COVID-19. Conclusion: There were more critical cases and a high mortality in elderly patients with COVID-19. An increased BUN level was an independent risk factor for death in elderly patients with COVID-19.
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